A 3d Electromechanical Fem-based Model for Cardiac Tissue
نویسندگان
چکیده
The CellDrum provides an experimental setup to investigate the electromechanics of a cardiac tissue construct and particularly the effect of drugs. Experimental data were used to develop a respective computational electromechanical model. Until now, the experiments have been performed with a thin tissue construct. Mechanically, it was modeled as a materially and geometrically nonlinear shell. Future experiments with thicker tissue are planned. Thus, the mechanical model needs to be modified. This study aims to predict the outcome of such experiments using a nonlinear 3D continuum formulation. Here, the action of one drug, verapamil, was taken into account. M.T. Duong, A. Jung, R. Frotscher and M. Staat
منابع مشابه
Finite-element-method (FEM) model generation of time-resolved 3D echocardiographic geometry data for mitral-valve volumetry
INTRODUCTION Mitral Valve (MV) 3D structural data can be easily obtained using standard transesophageal echocardiography (TEE) devices but quantitative pre- and intraoperative volume analysis of the MV is presently not feasible in the cardiac operation room (OR). Finite element method (FEM) modelling is necessary to carry out precise and individual volume analysis and in the future will form th...
متن کاملSmoothed Particle Hydrodynamics for Electrophysiological Modeling: An Alternative to Finite Element Methods
Finite element methods (FEM) are generally used in cardiac 3D-electromechanical modeling. For FEM modeling, a step of a suitable mesh construction is required, which is non-trivial and time-consuming for complex geometries. A meshless method is proposed to avoid meshing. The smoothed particle hydrodynamics (SPH) method was used to solve an electrophysiological model on a left ventricle extracte...
متن کاملA 3D elasto-plastic FEM program developed for reservoir Geomechanics simulations: Introduction and case studies
The development of yielded or failure zone due to an engineering construction is a subject of study in different disciplines. In Petroleum engineering, depletion from and injection of gas into a porous rock can cause development of a yield zone around the reservoir. Studying this phenomenon requires elasto-plastic analysis of geomaterial, in this case the porous rocks. In this study, which is a...
متن کاملExcitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current: A Simulation Study
Myocytes have been regarded as the main objectives in most cardiac modeling studies and attracted a lot of attention. Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function. This study proposed an integrated myocyte-I sac-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (I sac) on cardiac electrical exc...
متن کاملScaffold Free Bio-orthogonal Assembly of 3-Dimensional Cardiac Tissue via Cell Surface Engineering
There has been tremendous interest in constructing in vitro cardiac tissue for a range of fundamental studies of cardiac development and disease and as a commercial system to evaluate therapeutic drug discovery prioritization and toxicity. Although there has been progress towards studying 2-dimensional cardiac function in vitro, there remain challenging obstacles to generate rapid and efficient...
متن کامل